Duphaston FAQ

Q: Is duphaston safe for pregnant?

A: Dydrogesterone has been prescribed and used in over 10 million pregnancies worldwide. There have been no harmful effects exhibited due to the use of dydrogesterone while pregnant. Dydrogesterone is safe to use during pregnancy only when prescribed and indicated by a medical practitioner.

Q: What is the use of dydrogesterone tablets?

A: Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency. Threatened miscarriage. Habitual or recurrent miscarriage.

Q: I am 28 years old and two months pregnant. My doctor prescribed Duphaston 10 mg tablet a day. I checked the needs for this drug on the internet and now I am bit confused as to why I was asked to take this drug when I am pregnant. Is there a particular reason to take this drug during early stages of pregnancy? I am pregnant with my second child. Did not experience any complications with the first one and nor do I have any at this stage.

A: Duphaston is the brand name given to it by the company. The name of the medicine is a hormone called dydrogesterone (progesterone). This product is indicated in women trying to conceive if there is proven, documented deficiency of the progesterone hormone (during luteal phase). Once conception has taken place, progesterone hormone is indicated only in pregnancies due to assisted reproductive techniques such as IVF etc. or in cases of habitual abortion (repeated miscarriages). Misuse and overuse of progesterone can lead to a number of side effects including fetal death and spontaneous abortion (more so in the first three months of gestation), musculanisation of female fetus (such as unwanted hair on face), birth defects in babies such as cleft palate and heart defects.

Q: Why do pregnant women take progesterone?

A: Changing progesterone levels can contribute to abnormal menstrual periods and menopausal symptoms. Progesterone is also necessary for implantation of the fertilized egg in the uterus and for maintaining pregnancy. Lab-made progesterone is used to imitate the functions of the progesterone released by the ovaries.

Q: Can taking progesterone cause pregnancy symptoms?

A: Progesterone does cause some of the symptoms of early pregnancy, including some you may experience each month, like sore breasts, although increasing estrogen levels also contribute. ... You may also have spotting if progesterone levels don't maintain the uterine lining well.

Q: What does progesterone do during pregnancy?

A: One of progesterone's most important functions is its role in thickening the lining of the uterus each month. The enriched endometrial lining is prepared to receive and nourish a fertilized egg. If a pregnancy occurs, progesterone is produced in the placenta and levels remain elevated throughout the pregnancy.

Q: Alcohol

A: Interaction with alcohol is unknown. Please consult your doctor.

Q: Pregnancy

A: Unknown. Human and animal studies are not available. Please consult your doctor.

Q: Lactation

A: Duphaston 10mg Tablet is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.

Q: Dydrogesterone or progesterone?

A: Duphaston tablets 10mg contain dydrogesterone, a synthetic derivative of the female sex hormone progesterone, which means that its chemical structure closely resembles that of naturally produced progesterone and it therefore works in a similar way. However, unlike natural progesterone it is easily absorbed and can be taken in tablet form at relatively low concentrations, whereas natural progesterone is not well absorbed by the gastrointestinal system and until recently could only be administered by injection, but now a new form of natural progesterone, which has been micronized (reduced to tiny particles so that it is better absorbed) is now available. Duphaston 10 can substitute for progesterone in treating conditions that are the result of a lack of progesterone in the body including menstrual disorders, endometriosis and can be used as part of a hormone replacement therapy (HRT) regime to counteract the effect of oestrogen and reduce the risk of endometrial cancer. However, unlike other synthetic progestogen, dydrogesterone does not interfere with the beneficial effects of oestrogen, such as preventing bone loss and regulating cholesterol and it is not chemically related to testosterone, and therefore has no virilising effects (inducing male characteristics), like, hirsutism or acne.

Q: Is Duphaston a steroid?

A: Duphaston has a steroidal chemical structure which is very similar to the naturally produced steroidal female hormone progesterone.

Q: Is Duphaston safe?

A: Duphaston is safe if taken for prescribed duration in prescribed doses for an indication as advised by your doctor.