Duphaston Side Effects

Duphaston may cause the following side effects:

  • nausea,
  • vomiting,
  • headache,
  • dizziness,
  • weight gain,
  • swelling of the breasts,
  • anemia,
  • depression,
  • lethargy,
  • liver damage (loss of appetite, pain in the right upper abdomen, jaundice),
  • allergy and others.

Missed a dose of Duphaston

If you have missed a dose by chance, try to use it as soon as possible when you notice. However, if the time is closer to your next dosage, simply skip the medicine. In such cases, try not to take a double dosage.

Pregnancy or Breastfeeding

Dydrogesterone has been prescribed and used in over 10 million pregnancies worldwide. There have been no harmful effects exhibited due to the use of dydrogesterone while pregnant. Dydrogesterone is safe to use during pregnancy only when prescribed and indicated by a medical practitioner. Studies have not shown any incidence of decreased fertility due to dydrogesterone at therapeutic dose. The Ames test found no evidence of any potential mutagenic or toxicity properties.

You must consult a gynecologist for more details before consuming the medicine. Pregnant women can weigh the pros & cons of the drug with the help of a doctor before it is used.


There is not enough clinical data to support overdose in humans. The maximum dose of dydrogesterone administered to humans to date was 360 mg orally and the drug was found to be well-tolerated at this dose. There are no antidotes to overdose and treatment should be based on symptoms. In acute toxicity trials, the LD50 doses in rats were in excess of 4,640 mg/kg orally.