Duphastone dosage

You should take Duphaston tablets 10mg, with a glass of water, with or without food, once or twice daily. The dose of Duphaston 10 you take, how often your take it and for how long depends on what you are being treated for. You should continue to take your tablets for as long as your doctor recommends, which may be for 5 days, or taken continually for several days a month and repeated each menstrual cycle for several months, as needed; or taken continuously.

Treating endometriosis with Duphaston

Duphaston tablets 10mg contain dydrogesterone, a synthetic derivative of the female sex hormone progesterone, which means that its chemical structure closely resembles that of naturally produced progesterone and it therefore works in a similar way. During a normal menstrual cycle, progesterone (produced by the ovaries) acts on the endometrium and causes it to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs. If not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Endometriosis is the growth of endometrial tissue outside the uterus which behaves in the same way as uterine endometrium, including its response to progesterone. Duphaston 10 acts on the endometrium in all its locations to stop it growing, which alleviates symptoms of endometriosis including pain and bleeding.

Treating menstrual problems with Duphaston

Duphaston tablets 10mg contain dydrogesterone, a synthetic derivative of the female sex hormone progesterone, which means that its chemical structure closely resembles that of naturally produced progesterone and it therefore works in a similar way. A normal menstrual cycle is dependent on the interaction of several hormones, including oestrogen and progesterone produced by the ovaries as well other regulating hormones produced by the pituitary gland. If any of these hormones are not produced in the correct amounts this can disrupt the cycle and cause problems like amenorrhoea (menstrual periods that have stopped, are absent or irregular) and abnormal uterine bleeding during the menstrual cycle instead of at the end. Duphaston 10 can re-establish a regular menstrual cycle by helping to restore natural hormone levels.

Duphaston for hormone replacement therapy (HRT)

Duphaston tablets 10mg contain dydrogesterone, a synthetic derivative of the female sex hormone progesterone, which means that its chemical structure closely resembles that of naturally produced progesterone and it therefore works in a similar way. Taking oestrogen for hormone replacement therapy (HRT) helps reduce symptoms of menopause caused by oestrogen deficiency, including, hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy. Oestrogen also has several other beneficial actions in various metabolic processes including bone turnover and lipid (fat) metabolism, but its effect of thickening the endometrium (uterine lining), in the absence of progesterone, which inhibits endometrial growth, can lead to endometrial (uterine) cancer in some menopausal women taking oestrogen only HRT. Duphaston 10 counteracts the stimulating effect of oestrogen on the endometrium, reducing the risk of endometrial cancer, which can develop in response to an oestrogen, in women taking HRT for menopausal symptoms.

How long should you take Duphaston?

You should continue to take your Duphaston tablets 10mg for as long as your doctor recommends, which may be for 5 days, or taken continually for several days a month and repeated each menstrual cycle for several months, as needed; or taken continuously.

Medical uses

Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency:

  • Infertility due to luteal insufficiency
  • Threatened miscarriage
  • Habitual or recurrent miscarriage
  • Menstrual disorders
  • Premenstrual syndrome
  • Endometriosis

Dydrogesterone has also been registered as a component of menopausal hormone therapy to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus.